The intersection of chemical biology and nanotechnology offers vast opportunities to improve our understanding and treatment of human disease. The Finbloom lab will apply design principles found in biology and naturally occurring systems to create new classes of bioinspired nanomaterials to solve intractable biomedical problems. Some of the applications of our research include studying and overcoming mechanisms of antibiotic resistance, improving the oral delivery of probiotics to treat gastrointestinal disorders, designing injectable scaffolds for regenerative medicine, and advancing cancer detection and drug delivery.
Antimicrobial Drug Delivery with Nanomaterials
As a postdoc in the lab of Prof. Tejal Desai at UCSF, Joel developed a new class of polymeric drug carrier, capable of penetrating and adhering to bacterial infections to locally and controllably deliver combinations of synergistic antimicrobials. These drug carriers eradicated resistant bacterial biofilms and treated acute lung infections in mice. A central focus of this project was engineering the drug carrier biointerface to overcome biological barriers to drug delivery.